The interval between organ procurement and implantation is a vulnerable period in which the graft is deprived of perfusion. Cold static storage slows metabolism but cannot prevent the progressive oxygen debt that drives ischemia–reperfusion injury and limits the safe preservation time of donor organs.
OxoPreserve addresses this gap by exposing the harvested organ to a controlled hyperbaric oxygen environment during preservation. By raising the amount of oxygen physically dissolved in the preservation solution and tissue, the method aims to sustain aerobic metabolism, blunt reperfusion injury at the time of implantation, and extend the window during which an organ remains transplantable.
Rationale & potential benefits
- Maintains tissue oxygenation while the organ is outside the body.
- Aims to reduce ischemia–reperfusion injury after implantation.
- May extend safe preservation time and widen the donor pool.
- Compatible with conventional cold-storage workflows.
This page summarises the concept of OxoPreserve. Detailed methodology and supporting data will be added as the work is published.